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Prof. dr. P. (Peter) Timmerman

Protein-mimetic Chemistry
Faculty of Science
Van 't Hoff Institute for Molecular Sciences
Photographer: Onbekend

Visiting address
  • Science Park 904
  • Room number:C2.252
Postal address
  • Postbus 94157
    1090 GD Amsterdam
Contact details
  • Publications

    2019

    • Bernhagen, D., Jungbluth, V., Quilis, N. G., Dostalek, J., White, P. B., Jalink, K., & Timmerman, P. (2019). Bicyclic RGD Peptides with Exquisite Selectivity for the Integrin αvβ3 Receptor Using a “Random Design” Approach. ACS Combinatorial Science, 21(3), 198-206. https://doi.org/10.1021/acscombsci.8b00144 [details]
    • Bernhagen, D., Jungbluth, V., Quilis, N. G., Dostalek, J., White, P. B., Jalink, K., & Timmerman, P. (2019). High-Affinity α5β1-Integrin-Selective Bicyclic RGD Peptides Identified via Screening of Designed Random Libraries. ACS Combinatorial Science, 21(8), 598-607. https://doi.org/10.1021/acscombsci.9b00081 [details]
    • Cipriani, F., Bernhagen, D., García-Arévalo, C., González de Torre, I., Timmerman, P., & Carlos Rodríguez-Cabello, J. C. (2019). Bicyclic RGD peptides with high integrin αvβ3 and α5β1 affinity promote cell adhesion on elastin-like recombinamers. Biomedical Materials, 14(3), [035009]. https://doi.org/10.1088/1748-605X/aafd83 [details]
    • Streefkerk, D. E., Schmidt, M., Ippel, J. H., Hackeng, T. M., Nuijens, T., Timmerman, P., & van Maarseveen, J. H. (2019). Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation. Organic Letters, 21(7), 2095-2100. https://doi.org/10.1021/acs.orglett.9b00378 [details]

    2017

    • Bernhagen, D., De Laporte, L., & Timmerman, P. (2017). High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Analytical Chemistry, 89(11), 5991-5997. https://doi.org/10.1021/acs.analchem.7b00554 [details]

    2015

    • Smeenk, L. E. J., Timmers-Parohi, D., Benschop, J. J., Puijk, W. C., Hiemstra, H., van Maarseveen, J. H., & Timmerman, P. (2015). Reconstructing the Discontinuous and Conformational β1/β 3-Loop Binding Site on hFSH/hCG by Using Highly Constrained Multicyclic Peptides. ChemBioChem, 16(1), 91-99. https://doi.org/10.1002/cbic.201402540 [details]

    2013

    • Meuzelaar, H., Marino, K. A., Huerta-Viga, A., Panman, M. R., Smeenk, L. E. J., Kettelarij, A. J., ... Woutersen, S. (2013). Folding Dynamics of the Trp-Cage Miniprotein: Evidence for a Native-Like Intermediate from Combined Time-Resolved Vibrational Spectroscopy and Molecular Dynamics Simulations. The journal of Physical Chemistry. B, 117(39), 11490-11501. https://doi.org/10.1021/jp404714c [details]

    2012

    • Back, J. W., Frisch, C., Van Pee, K., Boschert, V., van Vught, R., Puijk, W., ... Timmerman, P. (2012). Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin. Protein Engineering Design and Selection (Print), 25(5), 251-259. https://doi.org/10.1093/protein/gzs012 [details]
    • Smeenk, L. E. J., Dailly, N., Hiemstra, H., van Maarseveen, J. H., & Timmerman, P. (2012). Synthesis of water-soluble scaffolds for peptide cyclization, labeling, and ligation. Organic Letters, 14(5), 1194-1197. https://doi.org/10.1021/ol203259a [details]
    • Smeenk, L. E. J., Hiemstra, H., van Maarseveen, J. H., & Timmerman, P. (2012). Functional mimicry of protein binding sites: Using CLIPS technology in combination with oxime ligation for the reconstruction of discontinuous epitopes. Journal of Peptide Science, 18/S1, S121. https://doi.org/10.1002/psc.2449 [details]

    2011

    • Niederfellner, G., Lammens, A., Mundigl, O., Georges, G. J., Schaefer, W., Schwaiger, M., ... Klein, C. (2011). Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies. Blood, 118(2), 358-367. https://doi.org/10.1182/blood-2010-09-305847 [details]
    • Snir, E., Joore, J., Timmerman, P., & Yitzchaik, S. (2011). Monitoring selectivity in kinase-promoted phosphorylation of densely packed peptide monolayers using label-free electrochemical detection. Langmuir, 27(17), 11212-11221. https://doi.org/10.1021/la202247m [details]

    2010

    • Timmerman, P., Shochat, S. G., Desmet, J., Barderas, R., Casal, J. I., Meloen, R. H., & Altschuh, D. (2010). Binding of CDR-derived peptides is mechanistically different from that of high-affinity parental antibodies. Journal of Molecular Recognition, 23(6), 559-568. https://doi.org/10.1002/jmr.1017 [details]

    2009

    • Timmerman, P., Barderas, R., Desmet, J., Altschuh, D., Shochat, S., Hollestelle, M. J., ... Meloen, R. H. (2009). A combinatorial approach for the design of complementarity-determining region-derived peptidomimetics with in vitro anti-tumoral activity. The Journal of Biological Chemistry, 284(49), 34126-34134. https://doi.org/10.1074/jbc.M109.041459 [details]
    • Timmerman, P., Puijk, W. C., Boshuizen, R. S., van Dijken, P., Slootstra, J. W., Beurskens, F. J., ... Meloen, R. H. (2009). Functional reconstruction of structurally complex epitopes using CLIPS™ technology. The Open Vaccine Journal, 2, 56-67. https://doi.org/10.2174/1875035400902010056 [details]

    2008

    • Barderas, R., Desmet, J., Timmerman, P., Meloen, R., & Casal, J. I. (2008). Affinity maturation of antibodies assisted by in silico modeling. Proceedings of the National Academy of Sciences of the United States of America, 105(26), 9029-9034. https://doi.org/10.1073/pnas.0801221105 [details]
    • Barderas, R., Shochat, S., Timmerman, P., Hollestelle, M. J., Martínez-Torrecuadrada, J. L., Höppener, J. W. M., ... Casal, J. I. (2008). Designing antibodies for the inhibition of gastrin activity in tumoral cell lines. International journal of cancer, 122(10), 2351-2359. https://doi.org/10.1002/ijc.23395 [details]
    • Hollestelle, M. J., Timmerman, P., Meloen, R. H., & Höppener, J. W. M. (2008). Characterization of gastrin-cholecystokinin 2 receptor interaction in relation to c-fos induction. Endocrine related cancer, 15(1), 301-309. https://doi.org/10.1677/ERC-07-0206 [details]
    • Korbakov, N., Timmerman, P., Lidich, N., Urbach, B., Sa'ar, A., & Yitzchaik, S. (2008). Acetylcholine detection at micromolar concentrations with the use of an artificial receptor-based fluorescence switch. Langmuir, 24(6), 2580-2587. https://doi.org/10.1021/la703010z [details]

    2018

    • Richelle, G., Schmidt, M., Hiemstra, H., Nuijens, T., van Maarseveen, J., & Timmerman, P. (2018). Multicyclic Peptides via Templated Tandem CLIPS/CuAAC Cyclizations. Journal of Peptide Science, 24(S2), S160. [P225]. https://doi.org/10.1002/psc.3127 [details]

    2017

    • Wentink, M. Q., Huijbers, E. J. M., Timmerman, P., & Griffioen, A. W. (2017). Reply to Marchiò et al.: Antitumor immune regulation by angiostatic therapy. Proceedings of the National Academy of Sciences of the United States of America, 114(16), E3166-E3167. https://doi.org/10.1073/pnas.1703074114 [details]

    2012

    • Smeenk, L. E. J., van Maarseveen, J. H., Dailly, N., & Timmerman, P. (2012). Preparation of novel bicyclic peptide mimetics via CLIPS technology, their antibody binding affinity and their use for structural mimicry of protein surfaces.

    2011

    • Timmerman, P., Smeenk, L. E. M., Dailly, N., & van Maarseveen, J. H. (2011). Improvements on CLIPS-technology.

    2010

    • Timmerman, P., & Dailly, N. (2010). Watersoluble CLIPS.
    • Timmerman, P., Dailly, N., van Maarseveen, J. H., & Smeenk, L. E. J. (2010). Double-CLIPS.

    2009

    • Timmerman, P. (2009). Hetzelfde, maar dan anders. (Oratiereeks; No. 332). Amsterdam: Vossiuspers UvA. [details]

    2008

    • Huber, A., Bachmann, M., Jennings, G., Tissot, A., Langedijk, J., Timmerman, P., ... Boshuizen, R. (2008). Circular CCR5 peptide conjugates for AIDS vaccination.
    • Timmerman, P., Puijk, W. C., & Meloen, R. H. (2008). Immunogenic compounds and protein mimics.
    This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list.
  • Ancillary activities
    • Pepscan Therapeutics B.V.
      Chief Scientific Officer