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The HIMS research in the field of Analytical Chemistry focuses on developing or greatly improving analytical techniques and methods, especially in the fields of separation science and applied mass spectrometry. Specific focus is on multi-dimensional separations and “hyphenated systems”, such as LC-MS.

Separations are crucial for analyzing complex samples and there is prodigious interest from other disciplines and from industry for HIMS' world-leading knowledge.

Application areas include synthetic polymers, proteins and other natural macromolecules, forensics, art science and food science. Data analysis and optimization ('chemometrics') are essential aspects of the research program.

The HIMS researchers work closely together with colleagues at Vrije Universiteit Amsterdam in a number of projects and in the Centre of Analytical Sciences Amsterdam (CASA).