Prof. dr. H. (Henk) Hiemstra
Synthetic Organic Chemistry
Faculty of Science
Van 't Hoff Institute for Molecular Sciences
Visiting address
- Science Park 904
Postal address
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Postbus 94157
1090 GD Amsterdam
Contact details
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Farewell lecture
As an emeritus professor of Synthetic Organic Chemistry Henk Hiemstra continues to contribute to the UvA chemistry research at the Van 't Hoff Institute of Molecular Sciences.
On 25 May 2018 he held his farewell lecture:
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Publications
2018
Horst, B., Wanner, M. J., Jørgensen, S. I., Hiemstra, H., & van Maarseveen, J. H. (2018). Total Synthesis of the Ortho-Hydroxylated Protoberberines (S)-Govaniadine, (S)-Caseamine, and (S)-Clarkeanidine via a Solvent-Directed Pictet-Spengler Reaction. Journal of Organic Chemistry, 83(24), 15110-15117. https://doi.org/10.1021/acs.joc.8b02378 [details]- Steemers, L., Wanner, M. J., van Leeuwen, B. R. C., Hiemstra, H., & van Maarseveen, J. H. (2018). Attempted [2]Catenane Synthesis via a Quasi[1]catenane by a Templated Backfolding Strategy. European Journal of Organic Chemistry, 2018(7), 874-878. https://doi.org/10.1002/ejoc.201701325 [details]
2017
- Liu, Y., Sauri, J., Mevers, E., Peczuh, M. W., Hiemstra, H., Clardy, J., Martin, G. E., & Williamson, R. T. (2017). Unequivocal determination of complex molecular structures using anisotropic NMR measurements. Science, 356(6333), Article 43. https://doi.org/10.1126/science.aam5349 [details]
- Steemers, L., Wanner, M. J., Ehlers, A. W., Hiemstra, H., & van Maarseveen, J. H. (2017). A Short Covalent Synthesis of an All-Carbon-Ring [2]Rotaxane. Organic Letters, 19(9), 2342-2345. https://doi.org/10.1021/acs.orglett.7b00877 [details]
- Steemers, L., Wanner, M. J., Lutz, M., Hiemstra, H., & van Maarseveen, J. H. (2017). Synthesis of spiro quasi[1]catenanes and quasi[1]rotaxanes via a templated backfolding strategy. Nature Communications, 8, Article 15392. https://doi.org/10.1038/ncomms15392 [details]
2016
- Breman, A. C., van der Heijden, G., van Maarseveen, J. H., Ingemann Jorgensen, S., & Hiemstra, H. (2016). Synthetic and Organocatalytic Studies of Quinidine Analogues with Ring-Size Modifications in the Quinuclidine Moiety. Chemistry-A European Journal, 22(40), 14247-14256. https://doi.org/10.1002/chem.201601917
- Kayhan, J., Wanner, M. J., Ingemann, S., van Maarseveen, J. H., & Hiemstra, H. (2016). Consecutive Pictet-Spengler Condensations toward Bioactive 8-Benzylprotoberberines: Highly Selective Total Syntheses of (+)-Javaberine A, (+)-Javaberine B, and (-)-Latifolian A. European Journal of Organic Chemistry, 2016(22), 3705-3708. https://doi.org/10.1002/ejoc.201600764 [details]
- Kleinnijenhuis, R. A., Timmer, B. J. J., Lutteke, G., Smits, J. M. M., de Gelder, R., van Maarseveen, J. H., & Hiemstra, H. (2016). Formal synthesis of solanoeclepin A: enantioselective allene diboration and intramolecular [2+2] photocycloaddition for the construction of the tricyclic core. Chemistry - A European Journal, 22(4), 1266-1269. https://doi.org/10.1002/chem.201504894 [details]
- Lutteke, G., Kleinnijenhuis, R. A., Beuving, R. J., de Gelder, R., Smits, J. M. M., van Maarseveen, J. H., & Hiemstra, H. (2016). Enantioselective Approach to the Right-Hand Substructure of Solanoeclepin A. European Journal of Organic Chemistry, 2016(35), 5845-5854. https://doi.org/10.1002/ejoc.201601094 [details]
- Pauli, G. F., Niemitz, M., Bisson, J., Lodewyk, M. W., Soldi, C., Shaw, J. T., Tantillo, D. J., Saya, J. M., Vos, K., Klein Nijenhuis, R. A., Hiemstra, H., Chen, S.-N., McAlpine, J. B., Lankin, D. C., & Friesen, J. B. (2016). Toward Structural Correctness: Aquatolide and the Importance of 1D Proton NMR FID Archiving. Journal of Organic Chemistry, 81(3), 878-889. https://doi.org/10.1021/acs.joc.5b02456 [details]
- Popovic, S., Wijsman, L., Landman, I. R., Sangster, M. F., Pastoors, D., Veldhorst, B. B., Hiemstra, H., & van Maarseveen, J. H. (2016). Fine-tuning the balance between peptide thioester cyclization and racemization. European Journal of Organic Chemistry, 2016(3), 443-446. https://doi.org/10.1002/ejoc.201501366 [details]
2015
- Breman, A. C., Telderman, S. E. M., van Santen, R. P. M., Scott, J. I., van Maarseveen, J. H., Ingemann, S., & Hiemstra, H. (2015). Cinchona alkaloid catalyzed sulfa-Michael addition reactions leading to enantiopure β-functionalized cysteines. Journal of Organic Chemistry, 80(21), 10561-10574. https://doi.org/10.1021/acs.joc.5b01660 [details]
- Ruiz-Olalla, A., Würdemann, M. A., Wanner, M. J., Ingemann, S., van Maarseveen, J. H., & Hiemstra, H. (2015). Organocatalytic Enantioselective Pictet-Spengler Approach to Biologically Relevant 1-Benzyl-1,2,3,4-Tetrahydroisoquinoline Alkaloids. Journal of Organic Chemistry, 80(10), 5125-5132. https://doi.org/10.1021/acs.joc.5b00509 [details]
- Saya, J. M., Vos, K., Klein Nijenhuis, R. A., van Maarseveen, J. H., Ingemann, S., & Hiemstra, H. (2015). Total synthesis of aquatolide. Organic Letters, 17(15), 3892-3894. https://doi.org/10.1021/acs.orglett.5b01888 [details]
- Smeenk, L. E. J., Timmers-Parohi, D., Benschop, J. J., Puijk, W. C., Hiemstra, H., van Maarseveen, J. H., & Timmerman, P. (2015). Reconstructing the Discontinuous and Conformational β1/β 3-Loop Binding Site on hFSH/hCG by Using Highly Constrained Multicyclic Peptides. ChemBioChem, 16(1), 91-99. https://doi.org/10.1002/cbic.201402540 [details]
- Wassenaar, J., Detz, R. J., de Boer, S. Y., Lutz, M., van Maarseveen, J. H., Hiemstra, H., & Reek, J. N. H. (2015). Enantioselective Synthesis of Tunable Chiral Clickphine P,N-Ligands and Their Application in Ir-Catalyzed Asymmetric Hydrogenation. Journal of Organic Chemistry, 80(7), 3634-3642. https://doi.org/10.1021/acs.joc.5b00438 [details]
2014
- Breman, A. C., Ruiz-Olalla, A., van Maarseveen, J. H., Ingemann, S., & Hiemstra, H. (2014). Synthesis of Quinuclidines by Intramolecular Silver-Catalysed Amine Additions to Alkynes. European Journal of Organic Chemistry, 2014(33), 7413-7425. https://doi.org/10.1002/ejoc.201403099 [details]
- Mons, E., Wanner, M. J., Ingemann, S., van Maarseveen, J. H., & Hiemstra, H. (2014). Organocatalytic Enantioselective Pictet-Spengler Reactions for the Syntheses of 1-Substituted 1,2,3,4-Tetrahydroisoquinolines. Journal of Organic Chemistry, 79(16), 7380-7390. https://doi.org/10.1021/jo501099h [details]
2013
- Popovic, S., Bieräugel, H., Detz, R. J., Kluwer, A. M., Koole, J. A. A., Streefkerk, D. E., Hiemstra, H., & van Maarseveen, J. (2013). Epimerization-Free C-Terminal Peptide Activation. Chemistry - A European Journal, 19(50), 16934-16937. https://doi.org/10.1002/chem.201303347 [details]
- Wanner, M. J., Ingemann, S., van Maarseveen, J. H., & Hiemstra, H. (2013). Total Synthesis of the Spirocyclic Oxindole Alkaloids Corynoxine, Corynoxine B, Corynoxeine, and Rhynchophylline. European Journal of Organic Chemistry, 2013(6), 1100-1106. https://doi.org/10.1002/ejoc.201201505 [details]
2012
- Breman, A. C., Smits, J. M. M., de Gelder, R., van Maarseveen, J. H., Ingemann, S., & Hiemstra, H. (2012). Enantioselective organocatalytic thiol addition to alpha,beta-unsaturated alpha-amino acid derivatives. Synlett, 23(15), 2195-2200. https://doi.org/10.1055/s-0032-1317081 [details]
- Kerschgens, I. P., Claveau, E., Wanner, M. J., Ingemann, S., van Maarseveen, J. H., & Hiemstra, H. (2012). Total syntheses of mitragynine, paynantheine and speciogynine via an enantioselective thiourea-catalysed Pictet-Spengler reaction. Chemical Communications, 48(100), 12243-12245. https://doi.org/10.1039/c2cc37023a [details]
- Rutters, J. P. A., Verdonk, Y., de Vries, R., Ingemann, S., Hiemstra, H., Levacher, V., & van Maarseveen, J. H. (2012). Synthesis of strained cyclic peptides via an aza-Michael-acyl-transfer reaction cascade. Chemical Communications, 48, 8084-8086. https://doi.org/10.1039/c2cc34121b [details]
- Smeenk, L. E. J., Dailly, N., Hiemstra, H., van Maarseveen, J. H., & Timmerman, P. (2012). Synthesis of water-soluble scaffolds for peptide cyclization, labeling, and ligation. Organic Letters, 14(5), 1194-1197. https://doi.org/10.1021/ol203259a [details]
- Smeenk, L. E. J., Hiemstra, H., van Maarseveen, J. H., & Timmerman, P. (2012). Functional mimicry of protein binding sites: Using CLIPS technology in combination with oxime ligation for the reconstruction of discontinuous epitopes. Journal of Peptide Science, 18/S1, S121. Advance online publication. https://doi.org/10.1002/psc.2449 [details]
2011
- Bleeker, P. M., Diergaarde, P. J., Ament, K., Schütz, S., Johne, B., Dijkink, J., Hiemstra, H., de Gelder, R., de Both, M. T. J., Sabelis, M. W., Haring, M. A., & Schuurink, R. C. (2011). Tomato-produced 7-epizingiberene and R-curcumene act as repellents to whiteflies. Phytochemistry, 72(1), 68-73. https://doi.org/10.1016/j.phytochem.2010.10.014 [details]
- Detz, R. J., Abiri, Z., le Griel, R., Hiemstra, H., & van Maarseveen, J. H. (2011). Enantioselective copper-catalysed propargylic substitution: synthetic scope study and application in formal total syntheses of (+)-anisomycin and (-)-cytoxazone. Chemistry - A European Journal, 17(21), 5921-5930. https://doi.org/10.1002/chem.201003727 [details]
- Herlé, B., Wanner, M. J., van Maarseveen, J. H., & Hiemstra, H. (2011). Total synthesis of (+)-yohimbine via an enantioselective organocatalytic Pictet-Spengler reaction. Journal of Organic Chemistry, 76(21), 8907-8912. https://doi.org/10.1021/jo201657n [details]
- Kinderman, S. S., van Maarseveen, J. H., & Hiemstra, H. (2011). Phosphine-catalyzed [3+2] annulation of cyanoallenes. Synlett, (12), 1693-1696. https://doi.org/10.1055/s-0030-1260804 [details]
- Lutteke, G., Kleinnijenhuis, R. A., Jacobs, I., Wrigstedt, P. J., Correia, A. C. A., Nieuwenhuizen, R., Hue, B. T. B., Goubitz, K., Peschar, R., van Maarseveen, J. H., & Hiemstra, H. (2011). Intramolecular butenolide allene photocycloadditions and ensuing retro-ene reactions of some photoadducts. European Journal of Organic Chemistry, 2011(17), 3146-3155. https://doi.org/10.1002/ejoc.201100245 [details]
2010
- Marcelli, T., & Hiemstra, H. (2010). Cinchona alkaloids in asymmetric organocatalysis. Synthesis, (8), 1229-1279. https://doi.org/10.1055/s-0029-1218699 [details]
2009
- Breman, A. C., Dijkink, J., van Maarseveen, J. H., Kinderman, S. S., & Hiemstra, H. (2009). Expedient pyrrolizidine synthesis by propargylsilane addition to N-acyliminium ions followed by gold-catalyzed α-allenyl amide cyclization. Journal of Organic Chemistry, 74(16), 6327-6330. https://doi.org/10.1021/jo901393y [details]
- Detz, R. J., Hiemstra, H., & van Maarseveen, J. H. (2009). Catalyzed propargylic substitution. European Journal of Organic Chemistry, (36), 6263-6276. https://doi.org/10.1002/ejoc.200900877 [details]
- Hiemstra, H. (2009). Introduction. In H. Hiemstra (Ed.), Compounds with all-carbon functions: alkanes (pp. 1-8). (Science of synthesis; No. 48). Thieme. [details]
- Nessen, M. A., Kramer, G., Back, J. W., Baskin, J. M., Smeenk, L. E. J., de Koning, L. J., van Maarseveen, J. H., de Jong, L., Bertozzi, C. R., Hiemstra, H., & de Koster, C. G. (2009). Selective enrichment of azide-containing peptides from complex mixtures. Journal of Proteome Research, 8(7), 3702-3711. https://doi.org/10.1021/pr900257z [details]
- Wanner, M. J., Boots, R. N. A., Eradus, B., de Gelder, R., van Maarseveen, J. H., & Hiemstra, H. (2009). Organocatalytic enantioselective total synthesis of (-)-arboricine. Organic Letters, 11(12), 2579-2581. https://doi.org/10.1021/ol900888e [details]
2008
- Berkheij, M., Dijkink, J., David, O. R. P., Sonke, T., IJzendoorn, D. R., Blaauw, R. H., van Maarseveen, J. H., Schoemaker, H. E., & Hiemstra, H. (2008). Synthesis of a naturally occurring diene-containing amino acid and its glutamyl dipeptide via n-acyliminium ion chemistry. European Journal of Organic Chemistry, (5), 914-924. https://doi.org/10.1002/ejoc.200701016 [details]
- Detz, R. J., Delville, M. M. E., Hiemstra, H., & van Maarseveen, J. H. (2008). Enantioselective copper-catalyzed propargylic amination. Angewandte Chemie, International Edition, 47(20), 3777-3780. https://doi.org/10.1002/anie.200705264 [details]
- Lutteke, G., AlHussainy, R., Wrigstedt, P. J., Hue, B. T. B., de Gelder, R., van Maarseveen, J. H., & Hiemstra, H. (2008). Formation of bicyclic pyrroles and furans through an enone allene photocycloaddition and fragmentation sequence. European Journal of Organic Chemistry, (5), 925-933. https://doi.org/10.1002/ejoc.200701017 [details]
- Miginiac, L., Kinderman, S. S., & Hiemstra, H. (2008). 3-Trimethylsilyl-1-propyne. In L. A. Paquette (Ed.), Encyclopedia of reagents for organic synthesis: 2nd edition Wiley. https://doi.org/10.1002/047084289X.rt335.pub2 [details]
- Sewgobind, N. V., Wanner, M. J., Ingemann, S., de Gelder, R., van Maarseveen, J. H., & Hiemstra, H. (2008). Enantioselective BINOL-phosphoric acid catalyzed Pictet-Spengler reactions of N-benzyltryptamine. Journal of Organic Chemistry, 73(16), 6405-6408. https://doi.org/10.1021/jo8010478 [details]
- Springer, J., Jansen, T. P., Ingemann, S., Hiemstra, H., & van Maarseveen, J. H. (2008). Improved auxiliary for the synthesis of medium-sized bis(lactams). European Journal of Organic Chemistry, (2), 361-367. https://doi.org/10.1002/ejoc.200700832 [details]
- Springer, J., de Cuba, K. R., Calvet-Vitale, S., Geenevasen, J. A. J., Hermkens, P. H. H., Hiemstra, H., & van Maarseveen, J. H. (2008). Backbone amide linker strategy for the synthesis of 1,4-triazole-containing cyclic tetra- and pentapeptides. European Journal of Organic Chemistry, (15), 2592-2600. https://doi.org/10.1002/ejoc.200800143 [details]
- Wanner, M. J., Hauwert, P., Schoemaker, H. E., de Gelder, R., van Maarseveen, J. H., & Hiemstra, H. (2008). Synthesis of enantiopure (S)-indolylglycine by organocatalyzed Friedel-Crafts alkylation of indole. European Journal of Organic Chemistry, (1), 180-185. https://doi.org/10.1002/ejoc.200700886 [details]
2018
- Richelle, G., Schmidt, M., Hiemstra, H., Nuijens, T., van Maarseveen, J., & Timmerman, P. (2018). Multicyclic Peptides via Templated Tandem CLIPS/CuAAC Cyclizations. Journal of Peptide Science, 24(S2), S160. Article P225. https://doi.org/10.1002/psc.3127 [details]
2013
- Ingemann, S., & Hiemstra, H. (2013). Cinchonas and cupreidines. In P. I. Dalko (Ed.), Comprehensive enantioselective organocatalysis: catalysts, reactions, and applications. - Vol. 1: Privileged catalysts (pp. 119-160). Wiley-VCH. https://doi.org/10.1002/9783527658862.ch6 [details]
2011
- Wanner, M. J., Claveau, E., van Maarseveen, J. H., & Hiemstra, H. (2011). Enantioselective syntheses of corynanthe alkaloids by chiral bronsted Acid and palladium catalysis. Chemistry: A European Journal, 17(49), 13680-13683. https://doi.org/10.1002/chem.201103150 [details]
2015
- Hiemstra, H. (2015). [Review of: P.W.N.M. van Leeuwen (2014) C-1 building blocks in organic synthesis: workbench edition]. Synthesis, 47(17), 2690. https://doi.org/10.1055/s-0035-1560341 [details]
Membership / relevant position
- Hiemstra, H. (2018). Member of International Advisory Board, Organic Division of the Czech Chemical Society.
- Hiemstra, H. (2018). American Chemical Society.
- Hiemstra, H. (2018). Koninklijke Nederlandse Chemische Vereniging.
- Hiemstra, H. (2017). Member of the Jury Organic Chemistry Prize, Organic Division of the Czech Chemical Society.
- Hiemstra, H. (2017). Chairman Research Committee, HRSMC.
- Hiemstra, H. (2017). Member VICI Jury, NWO.
- Hiemstra, H. (2017). Member, Royal Holland Society of Sciences and Humanities (KHMW).
- Hiemstra, H. (2016). Member of the Program Committee, 27th European Colloquium on Heterocyclic Chemistry, Amsterdam.
- Hiemstra, H. (2016). Chairman of the Research Committee, HRSMC.
- Hiemstra, H. (2016). Member of the vici jury, NWO.
- Hiemstra, H. (2016). Member of the International Advisory Board, Organic Division of the Czech Chemical Society.
- Hiemstra, H. (2016). • Elected Member, Royal Holland Society of Sciences and Humanities (KHMW).
- Hiemstra, H. (2016). Member of the Organizing Committee, 5th HRSMC Summer School on Organic Synthesis, Maastricht.
Media appearance
- Hiemstra, H. (06-10-2021). Henk Hiemstra in De Volkskrant about the Nobel Prize in Chemistry for organocatalysis De Volkskrant. Henk Hiemstra in De Volkskrant about the Nobel Prize in Chemistry for organocatalysis. https://www.volkskrant.nl/wetenschap/winnaars-nobelprijs-voor-scheikunde-ontwikkelden-gereedschap-om-moleculen-te-bouwen~b913a917/?referrer=…
Journal editor
- Hiemstra, H. (reviewer) (2016). Molecules (Journal).
Others
- Hiemstra, H. (participant) (2016). AkzoNobel Afstudeerprijs voor Chemie en Procestechnologie (other).
2017
2017
- Lutz, M., van Maarseveen, J., Hiemstra, H., Wanner, M. & Steemers, L. (2017). CCDC 1517772: Experimental Crystal Structure Determination. The Cambridge Structural Database. https://doi.org/10.5517/ccdc.csd.cc1mycdb
2016
- Kleinnijenhuis, R. A., Smits, J. M. M., Beuving, R. J., de Gelder, R., Lutteke, G., Hiemstra, H. & van Maarseveen, J. (2016). CCDC 1502312: Experimental Crystal Structure Determination. The Cambridge Structural Database. https://doi.org/10.5517/ccdc.csd.cc1mf8p0
- van Maarseveen, J., Hiemstra, H., Lutteke, G., de Gelder, R., Smits, J. M. M., Beuving, R. J. & Kleinnijenhuis, R. A. (2016). CCDC 1502313: Experimental Crystal Structure Determination. The Cambridge Structural Database. https://doi.org/10.5517/ccdc.csd.cc1mf8q1
- de Gelder, R., van Maarseveen, J., Lutteke, G., Smits, J. M. M., Beuving, R. J., Hiemstra, H. & Kleinnijenhuis, R. A. (2016). CCDC 1502314: Experimental Crystal Structure Determination. The Cambridge Structural Database. https://doi.org/10.5517/ccdc.csd.cc1mf8r2
- Kleinnijenhuis, R. A., De Gelder, R., Smits, J. M. M., Hiemstra, H., Timmer, B., van Maarseveen, J. & Lutteke, G. (2016). CCDC 1420759: Experimental Crystal Structure Determination. The Cambridge Structural Database. https://doi.org/10.5517/cc1jpdyk
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Ancillary activities
No ancillary activities
Horst, B., Wanner, M. J., Jørgensen, S. I., Hiemstra, H., & van Maarseveen, J. H. (2018). Total Synthesis of the Ortho-Hydroxylated Protoberberines (S)-Govaniadine, (S)-Caseamine, and (S)-Clarkeanidine via a Solvent-Directed Pictet-Spengler Reaction. Journal of Organic Chemistry, 83(24), 15110-15117.