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uva.nl
Van 't Hoff Institute for Molecular Sciences null

Research facilities

HIMS has an extensive fleet of high quality analytical instrumentation, such as NMR, EPR, UV-Vis, HPLC and MS. HIMS offers companies - in particular small and medium enterprises (SME's) - unique access to this infrastructure, scientific software and related knowhow. HIMS scientists are always open to consider new collaborations and partnerships.

Below is a list of services we provide on regular base to third parties. More analyses can be performed upon request.

Please contact HIMS manager Marcel Bartels: M.J.Bartels@uva.nl, phone 020 525 8529. Also see our spin-off Spark904.

NMR spectrum service

  • 1D for H, C, P, F etc.
  • 2D for HSQC, NOESY etc.

NMR dedicated service

Spectrum interpretation for all nuclei measured with NMR

MS spectrum service

Accurate mass measurements for publication purposes:

  • Ionisation techniques like EI and FI coupled to GC
  • Probe available for FD and direct insertion
  • Electrospray / Coldspray

FD and Coldspray are especially suitable for instable compounds

MS-based proteomics

  • Qualitative proteomics– protein identification from gel separated or liquid samples by LC-MS/MS.
  • Quantitative targeted proteomics – using SWATH technology
  • Quantitative proteomics – using isobaric or isotopic labelling with iTRAQ and SILAC reagents.
  • Phosphorylation analysis (ID and quantitative) and other PTMs
  • Biological mass spectrometry – various analytical measurements for protein, peptide and small molecule structure determination and mass determination of proteins are offered.

Surface analysis

  • Adsorption of gasses and vapours
  • Mercury porosimetry

Vibrational Circular Dichroism spectroscopy service

  • Measurement of VCD spectra
  • Absolute configuration determination
  • Modelling services