Dr. F. (Francesco) Mutti
Faculty of Science
Van 't Hoff Institute for Molecular Sciences
Visiting address
- Science Park 904
- Room number:C2.252
Postal address
- Postbus 94157
1090 GD Amsterdam
Contact details
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Publications
2021
- Corrado, M. L., Knaus, T., & Mutti, F. G. (2021). High Regio- and Stereoselective Multi-enzymatic Synthesis of All Phenylpropanolamine Stereoisomers from beta-Methylstyrene. ChemBioChem, 22(13), 2345-2350. https://doi.org/10.1002/cbic.202100123
- Corrado, M. L., Tseliou, V., Houwman, J. A., Böhmer, W., Vilím, J., Masman, M. F., Knaus, T., & Mutti, F. G. (2021). Hydrogen-borrowing conversion of alcohols into optically active primary amines by combination of alcohol dehydrogenases and amine dehydrogenases. In J. Whittall, & P. W. Sutton (Eds.), Applied Biocatalysis: The Chemist's Enzyme Toolkit (pp. 455-468). Wiley. https://doi.org/10.1002/9781119487043.ch11 [details]
- Tseliou, V., Böhmer, W., Corrado, M. L., Masman, M. F., Knaus, T., & Mutti, F. G. (2021). Asymmetric reductive amination of ketones catalysed by amine dehydrogenases. In J. Whittall, & P. W. Sutton (Eds.), Applied Biocatalysis: The Chemist's Enzyme Toolkit (pp. 221-231). Wiley. https://doi.org/10.1002/9781119487043.ch5 [details]
- Tseliou, V., Schilder, D., Masman, M. F., Knaus, T., & Mutti, F. G. (2021). Generation of Oxidoreductases with Dual Alcohol Dehydrogenase and Amine Dehydrogenase Activity. Chemistry-A European Journal, 27(10), 3315-3325. https://doi.org/10.1002/chem.202003140
- Vilím, J., Knaus, T., & Mutti, F. (2021). Aerobic synthesis of aromatic nitriles from alcohols and ammonia using galactose oxidase. In J. Whittall, & P. W. Sutton (Eds.), Applied Biocatalysis: The Chemist's Enzyme Toolkit (pp. 449-455). Wiley. https://doi.org/10.1002/9781119487043.ch11 [details]
2020
Böhmer, W., Koenekoop, L., Simon, T., & Mutti, F. G. (2020). Parallel Interconnected Kinetic Asymmetric Transformation (PIKAT) with an Immobilized ω-Transaminase in Neat Organic Solvent. Molecules, 25(9), [2140]. https://doi.org/10.3390/molecules25092140 [details]- Böhmer, W., Volkov, A., Engelmark Cassimjee, K., & Mutti, F. G. (2020). Continuous Flow Bioamination of Ketones in Organic Solvents at Controlled Water Activity using Immobilized ω-Transaminases. Advanced Synthesis & Catalysis, 362(9), 1858-1867. https://doi.org/10.1002/adsc.201901274 [details]
- Tseliou, V., Knaus, T., Vilím, J., Masman, M. F., & Mutti, F. G. (2020). Kinetic Resolution of Racemic Primary Amines Using Geobacillus stearothermophilus Amine Dehydrogenase Variant. ChemCatChem, 12(8), 2184-2188. https://doi.org/10.1002/cctc.201902085 [details]
- Vilím, J., Knaus, T., & Mutti, F. G. (2020). Biocatalyzed Aerobic Oxidation Reaction. In E. Mejía (Ed.), Catalytic Aerobic Oxidations (pp. 131-180). (Catalysis Series; No. 39). Royal Society of Chemistry. https://doi.org/10.1039/9781839160332-00131 [details]
2019
- Bohmer, W., Knaus, T., Volkov, A., Slot, T. K., Shiju, N. R., Cassimjee, K. E., & Mutti, F. G. (2019). Highly efficient production of chiral amines in batch and continuous flow by immobilized ω-transaminases on controlled porosity glass metal-ion affinity carrier. Journal of Biotechnology, 291, 52-60. https://doi.org/10.1016/j.jbiotec.2018.12.001 [details]
- Cariati, L., Oliverio, M., Mutti, F. G., Bonacci, S., Knaus, T., Costanzo, P., & Procopio, A. (2019). Hydrolases-mediated transformation of oleuropein into demethyloleuropein. Bioorganic Chemistry, 84, 384-388. https://doi.org/10.1016/j.bioorg.2018.12.005 [details]
- Corrado, M. L., Knaus, T., & Mutti, F. G. (2019). Regio- and stereoselective multi-enzymatic aminohydroxylation of β-methylstyrene using dioxygen, ammonia and formate. Green Chemistry, 21(23), 6246-6251. https://doi.org/10.1039/c9gc03161h [details]
- Gacs, J., Zhang, W., Knaus, T., Mutti, F. G., Arends, I. W. C. E., & Hollmann, F. (2019). A Photo-Enzymatic Cascade to Transform Racemic Alcohols into Enantiomerically Pure Amines. Catalysts, 9(4), [305]. https://doi.org/10.3390/catal9040305 [details]
- Houwman, J. A., Knaus, T., Costa, M., & Mutti, F. G. (2019). Efficient synthesis of enantiopure amines from alcohols using resting E. coli cells and ammonia. Green Chemistry, 21(14), 3846-3857. https://doi.org/10.1039/c9gc01059a
- Musa, M. M., Hollmann, F., & Mutti, F. G. (2019). Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods. Catalysis Science & Technology, 9(20), 5487-5503. https://doi.org/10.1039/c9cy01539f [details]
- Tseliou, V., Knaus, T., Masman, M. F., Corrado, M. L., & Mutti, F. G. (2019). Generation of amine dehydrogenases with increased catalytic performance and substrate scope from ε-deaminating L-Lysine dehydrogenase. Nature Communications, 10, [3717]. https://doi.org/10.1038/s41467-019-11509-x [details]
- Tseliou, V., Masman, M. F., Böhmer, W., Knaus, T., & Mutti, F. G. (2019). Mechanistic Insight into the Catalytic Promiscuity of Amine Dehydrogenases: Asymmetric Synthesis of Secondary and Primary Amines. ChemBioChem, 20(6), 800-812. https://doi.org/10.1002/cbic.201800626 [details]
2018
- Bohmer, W., Knaus, T., & Mutti, F. G. (2018). Hydrogen-Borrowing Alcohol Bioamination with Coimmobilized Dehydrogenases. ChemCatChem, 10(4), 731-735. https://doi.org/10.1002/cctc.201701366 [details]
- Corrado, M. L., Knaus, T., & Mutti, F. G. (2018). A Chimeric Styrene Monooxygenase with Increased Efficiency in Asymmetric Biocatalytic Epoxidation. ChemBioChem, 19(7), 679-686. https://doi.org/10.1002/cbic.201700653 [details]
- Knaus, T., Tseliou, V., Humphreys, L. D., Scrutton, N. S., & Mutti, F. G. (2018). A biocatalytic method for the chemoselective aerobic oxidation of aldehydes to carboxylic acids. Green Chemistry, 20(17), 3931-3943. https://doi.org/10.1039/c8gc01381k [details]
- Vilím, J., Knaus, T., & Mutti, F. G. (2018). Catalytic Promiscuity of Galactose Oxidase: A Mild Synthesis of Nitriles from Alcohols, Air, and Ammonia. Angewandte Chemie, International Edition, 57(43), 14240-14244. https://doi.org/10.1002/anie.201809411, https://doi.org/10.1002/ange.201809411 [details]
- Vilím, J., Knaus, T., & Mutti, F. G. (2018). Catalytic Promiscuity of Galactose Oxidase: A Mild Synthesis of Nitriles from Alcohols, Air, and Ammonia. Angewandte Chemie, 130(43), 14436-14440. https://doi.org/10.1002/ange.201809411, https://doi.org/10.1002/anie.201809411 [details]
- Zhang, W., Fernandez-Fueyo, E., Ni, Y., van Schie, M., Gacs, J., Renirie, R., ... Hollmann, F. (2018). Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalizations. Nature Catalysis, 1(1), 55-62. https://doi.org/10.1038/s41929-017-0001-5 [details]
2017
- Knaus, T., & Mutti, F. G. (2017). Biocatalytic hydrogen-borrowing cascades. Chimica Oggi, 35(5, special issue), 34-37. [details]
- Knaus, T., Böhmer, W., & Mutti, F. G. (2017). Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds. Green Chemistry, 19(2), 453-463. https://doi.org/10.1039/c6gc01987k [details]
- Knaus, T., Cariati, L., Masman, M. F., & Mutti, F. G. (2017). In vitro biocatalytic pathway design: orthogonal network for the quantitative and stereospecific amination of alcohols. Organic & Biomolecular Chemistry, 15(39), 8313-8325. https://doi.org/10.1039/c7ob01927k
2016
- Both, P., Busch, H., Kelly, P. P., Mutti, F. G., Turner, N. J., & Flitsch, S. L. (2016). Ganzzellen‐Biokatalysator für stereoselektive C‐H‐Aminierungen. Angewandte Chemie, 128(4), 1533-1536. https://doi.org/10.1002/ange.201510028, https://doi.org/10.1002/anie.201510028 [details]
- Both, P., Busch, H., Kelly, P. P., Mutti, F. G., Turner, N. J., & Flitsch, S. L. (2016). Whole-cell biocatalysts for stereoselective C-H amination reactions. Angewandte Chemie, International Edition, 55(4), 1511-1513. https://doi.org/10.1002/anie.201510028, https://doi.org/10.1002/ange.201510028 [details]
- Knaus, T., Paul, C. E., Levy, C. W., de Vries, S., Mutti, F. G., Hollmann, F., & Scrutton, N. S. (2016). Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes. Journal of the American Chemical Society, 138(3), 1033-1039. https://doi.org/10.1021/jacs.5b12252 [details]
- Mutti, F. G., Fuchs, C., & Kroutil, W. (2016). Asymmetric amination of ketones employing ω-TAs in organic solvents. In J. Whittall, P. W. Sutton, & W. Kroutil (Eds.), Practical methods for biocatalysis and biotransformations (Vol. 3, pp. 171-176). Chichester: Wiley. https://doi.org/10.1002/9781118697856.ch06 [details]
- Sattler, J. H., Fuchs, M., Mutti, F. G., & Kroutil, W. (2016). Amination of primary alcohols via a redox-neutral biocascade. In J. Whittall, P. W. Sutton, & W. Kroutil (Eds.), Practical methods for biocatalysis and biotransformations (Vol. 3, pp. 215-218). Chichester: Wiley. https://doi.org/10.1002/9781118697856.ch08 [details]
2015
- Holzer, A. K., Hiebler, K., Mutti, F. G., Simon, R. C., Lauterbach, L., Lenz, O., & Kroutil, W. (2015). Asymmetric biocatalytic amination of ketones at the expense of NH3 and molecular hydrogen. Organic Letters, 17(10), 2431-2433. https://doi.org/10.1021/acs.orglett.5b01154
- Knaus, T., Mutti, F. G., Humphreys, L. D., Turner, N. J., & Scrutton, N. S. (2015). Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes. Organic & Biomolecular Chemistry, 13(1), 223-233. https://doi.org/10.1039/c4ob02282c
- Mutti, F. G., Knaus, T., Scrutton, N. S., Breuer, M., & Turner, N. J. (2015). Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades. Science, 349(6255), 1525-1529. https://doi.org/10.1126/science.aac9283 [details]
2020
- Mutti, F., Tseliou, V., Knaus, T., & Masman, M. F. (2020). L-Lysine epsilon-dehydrogenase variants and uses thereof. (Patent No. WO 2020165417 A1 20200130).
- Mutti, F., Vilím, J., & Knaus, T. (2020). Process for the manufacture of nitrile compounds. (Patent No. WO 2020020844 A1 20200130).
2015
- Baldenius, K., Breuer, M., Ditrich, K., Navickas, V., Mutti, F., Knaus, T., & Turner, N. (2015). Redox self-sufficient bioamination of alcohols.
Award
- Gargano, A., Mutti, F. & Peters, R. (2020). grant EnDeP.
Media appearance
- Mutti, F. (01-04-2019). Sustainable synthesis of chiral amines: the HIMS-Biocat way The Project Repository Journal / European Dissemination Media Agency (EDMA). Sustainable synthesis of chiral amines: the HIMS-Biocat way. http://edition.pagesuite-professional.co.uk/html5/reader/production/default.aspx?pubname=&edid=3fc3875c-b9c5-4de1-a66a-3f0981761e99
- Mutti, F. (01-10-2018). Molecular science: The importance of sustainable manufacturing of chiral amines Open Access Government. Molecular science: The importance of sustainable manufacturing of chiral amines. http://edition.pagesuite-professional.co.uk/html5/reader/production/default.aspx?pubname=&edid=cf9996f7-b194-4d40-bb84-559aecb6d4b8
- Mutti, F. (28-08-2018). Developing new pathways for biocatalytic cascades EU Research. Developing new pathways for biocatalytic cascades. http://hims.uva.nl/content/news/2018/08/hims-biocatalysis-project-showcased-in-eu-research-magazine.html
- Mutti, F. (28-08-2018). Developing new pathways for biocatalytic cascades. Developing new pathways for biocatalytic cascades. https://issuu.com/euresearcher/docs/eu_research_16_digital_magazine_fin
Journal editor
- Mutti, F. (editor) (2017-). Amsterdam Science (Journal).
Talk / presentation
- Mutti, F. (speaker) (3-2020). Continuous flow biocatalysis for chiral amine synthesis, Flow Chemistry Europe 2020, Cambridge.
- Mutti, F. (speaker) (22-11-2019). Novel oxidoreductases: from enzyme engineering to biocatalytic cascades, Novartis.
- Mutti, F. (speaker) (21-11-2019). Novel oxidoreductases: enzyme engineering and biocatalytic cascades for sustainable chemistry, Swiss Industrial Biocatalysis Consortium (SIBC).
- Mutti, F. (speaker) (15-11-2019). Generation of amine dehydrogenases from an ε-deaminating L-lysine dehydrogenase, Dutch Biocatalysis Symposium, Amersfoort.
- Mutti, F. (speaker) (2019). Sustainable chemistry via biocatalytic cascades using novel oxidoreductases, XXII SINAQO—South American Organic Chemistry Conference, Mendoza.
- Mutti, F. (speaker) (27-6-2018). Maximizing the atom efficiency of redox reactions: Exploiting the exquisite selectivity of oxidoreductases, Biotech France 2018, Paris.
- Mutti, F. (speaker) (16-11-2017). One-pot and atom-efficient conversion of alcohols to enantiopure amines via biocatalytic cascades, HRSMC Symposium, Amsterdam.
- Mutti, F. (speaker) (2017). Biocatalytic cascades for the one-pot amination of alcohols using oxidoreductases, Biotrans 2013, Budapest.
Others
- Mutti, F. (organiser) (20-11-2020). Dutch Biocatalysis Symposium 2020. Symposium (organising a conference, workshop, ...).
- Mutti, F. (participant) & Tseliou, V. (participant) (20-11-2020). Dutch Biocatalysis Symposium 2020. participating in symposium (participating in a conference, workshop, ...).
- Mutti, F. (participant) (3-2020). Flow Chemistry Europe 2020, Cambridge. participating in conference (participating in a conference, workshop, ...).
- Mutti, F. (host) (1-3-2019 - 31-12-2019). Federico Groci (hosting a visitor).
- Mutti, F. (organiser) (2019). BioTrans 2019, Groningen. International Conference on Biocatalysis, Member of the scientific organizing committee (organising a conference, workshop, ...).
- Mutti, F. (host) (1-2-2017 - 31-8-2017). Alejandro Orden (hosting a visitor).
2020
- Corrado, M. L. (2020). Multi‐enzymatic routes for the targeted synthesis of enantiopure vicinal amino alcohols. [details]
- Tseliou, V. (2020). Expanding the catalytic activity of amine dehydrogenases: Rational enzyme engineering via computational analysis and application in organic synthesis. [details]
- Vilím, J. (2020). Bio-catalytic cascades and molecular oxygen-accessing amines and nitriles. [details]
This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list. -
Ancillary activities
- No ancillary activities
Böhmer, W., Koenekoop, L., Simon, T., & Mutti, F. G. (2020). Parallel Interconnected Kinetic Asymmetric Transformation (PIKAT) with an Immobilized ω-Transaminase in Neat Organic Solvent. Molecules, 25(9), [2140].