Prof. dr. R. (Ron) Wever
Biocatalysis and Bio-organic Chemistry
Faculty of Science
Van 't Hoff Institute for Molecular Sciences
Visiting address
- Science Park 904
- Room number: C2.225
Postal address
- Postbus 94157
1090 GD Amsterdam
Contact details
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Publications
2022
Chen, S., Zhang, J., Zeng, Z., Dai, Z., Wang, Q., Wever, R., Hollmann, F., & Zhang, W. (2022). Chemoenzymatic intermolecular haloether synthesis. Molecular Catalysis, 517, [112061]. https://doi.org/10.1016/j.mcat.2021.112061 [details]- Li, H., Younes, S. H. H., Chen, S., Duan, P., Cui, C., Wever, R., Zhang, W., & Hollmann, F. (2022). Chemoenzymatic Hunsdiecker-Type Decarboxylative Bromination of Cinnamic Acids. ACS Catalysis, 12(8), 4554-4559. https://doi.org/10.1021/acscatal.2c00485 [details]
- Supikova, K., Kosinova, A., Vavrusa, M., Koplikova, L., François, A., Pospisil, J., Zatloukal, M., Wever, R., Hartog, A., & Gruz, J. (2022). Sulfated phenolic acids in plants. Planta, 255(6), [124]. https://doi.org/10.1007/s00425-022-03902-6 [details]
2021
- Wever, R., Renirie, R., & Hollmann, F. (2021). Vanadium Chloroperoxidases as Versatile Biocatalysts. In M. Sutradhar, J. A. L. da Silva, & A. J. L. Pombeiro (Eds.), Vanadium Catalysis (pp. 548-563). (Catalysis Series; No. 41). Royal Society of Chemistry. https://doi.org/10.1039/9781839160882-00548 [details]
2020
- Höfler, G. T., But, A., Younes, S. H. H., Wever, R., Paul, C. E., Arends, I. W. C. E., & Hollmann, F. (2020). Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale. ACS Sustainable Chemistry & Engineering, 8(7), 2602-2607. https://doi.org/10.1021/acssuschemeng.9b07494 [details]
- Wever, R., & Hartog, A. F. (2020). Easy Sulphation of Phenols by a Bacterial Arylsulphotransferase. In J. Whitall, & P. W. Sutton (Eds.), Applied Biocatalyisis: the Chemist’s Toolbox (pp. 381-386). Wiley.
- Xu, X., But, A., Wever, R., & Hollmann, F. (2020). Towards Preparative Chemoenzymatic Oxidative Decarboxylation of Glutamic Acid. ChemCatChem, 12(8), 2180-2183. https://doi.org/10.1002/cctc.201902194 [details]
- Yuan, B., Mahor, D., Fei, Q., Wever, R., Alcalde, M., Zhang, W., & Hollmann, F. (2020). Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions. ACS Catalysis, 10(15), 8277-8284. https://doi.org/10.1021/acscatal.0c01958 [details]
2019
- Younes, S. H. H., Tieves, F., Lan, D., Wang, Y., Süss , P., Brundiek, H., ... Hollmann, F. (2019). Chemoenzymatic Halocyclization of γ,δ‐Unsaturated Carboxylic Acids and Alcohols. ChemSusChem, 13(1), 97-101. https://doi.org/10.1002/cssc.201902240 [details]
2018
- Wever, R., Krenn, B. E., & Renirie, R. (2018). Marine Vanadium-Dependent Haloperoxidases, Their Isolation, Characterization, and Application. In B. S. Moore (Ed.), Marine Enzymes and Specialized Metabolism (Vol. B, pp. 141-201). (Methods in Enzymology; Vol. 605). Cambridge: Academic Press. https://doi.org/10.1016/bs.mie.2018.02.026 [details]
- Zhang, W., Fernandez-Fueyo, E., Ni, Y., van Schie, M., Gacs, J., Renirie, R., ... Hollmann, F. (2018). Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalizations. Nature Catalysis, 1(1), 55-62. https://doi.org/10.1038/s41929-017-0001-5 [details]
2017
- But, A., van der Wijst, E., Le Notre, J., Wever, R., Sanders, J. P. M., Bitter, J. H., & Scott, E. L. (2017). Unusual differences in the reactivity of glutamic and aspartic acid in oxidative decarboxylation reactions. Green Chemistry, 19(21), 5178-5186. https://doi.org/10.1039/c7gc02137b
- Dong, J. J., Fernández-Fueyo, E., Li, J., Guo, Z., Renirie, R., Wever, R., & Hollmann, F. (2017). Halofunctionalization of alkenes by vanadium chloroperoxidase from Curvularia inaequalis. Chemical Communications, 53(46), 6207-6210. https://doi.org/10.1039/c7cc03368k [details]
- Prinsen, P., Narani, A., Hartog, A. F., Wever, R., & Rothenberg, G. (2017). Dissolving Lignin in Water through Enzymatic Sulfation with Aryl Sulfotransferase. ChemSusChem, 10(10), 2267-2273. https://doi.org/10.1002/cssc.201700376 [details]
- Wever, R., & Barnett, P. (2017). Vanadium Chloroperoxidases: The Missing Link in the Formation of Chlorinated Compounds and Chloroform in the Terrestrial Environment? Chemistry - An Asian Journal, 12(16), 1997-2007. https://doi.org/10.1002/asia.201700420
- Wever, R., Corr, M. J., Goss, R. J. M., & Kamer, P. (2017). Biocatalysis. In P. C. J. Kamer, D. Vogt, & J. W. Thybaut (Eds.), Contemporary Catalysis: Science, Technology and Applications (pp. 249-276). London: The Royal Society of Chemistry. [details]
- Wever, R., Goss, R. J. M., Tong, X., & Hartog, A. F. (2017). An Introduction to Biocatalysis. In P. C. J. Kamer, D. Vogt, & J. W. Thybaut (Eds.), Contemporary Catalysis: Science, Technology and Applications (pp. 131-155). London: The Royal Society of Chemistry. [details]
2016
- Fernández-Fueyo, E., Younes, S. H. H., van Rootselaar, S., Aben, R. W. M., Renirie, R., Wever, R., ... Hollmann, F. (2016). A Biocatalytic Aza-Achmatowicz Reaction. ACS Catalysis, 6(9), 5904-5907. https://doi.org/10.1021/acscatal.6b01636 [details]
- Hartog, L., & Wever, R. (2016). Sulfation made easy: A new versatile donor for enzymatic sulfation by a bacterial arylsulfotransferase. Journal of Molecular Catalysis B-Enzymatic, 129, 43-46. https://doi.org/10.1016/j.molcatb.2016.04.007
2015
- Fernández-Fueyo, E., van Wingerden, M., Renirie, R., Wever, R., Ni, Y., Holtmann, D., & Hollmann, F. (2015). Chemoenzymatic halogenation of phenols by using the haloperoxidase from Curvularia inaequalis. ChemCatChem, 7(24), 4035-4038. https://doi.org/10.1002/cctc.201500862 [details]
- Gupta, R., Hou, G., Renirie, R., Wever, R., & Polenova, T. (2015). 51V NMR Crystallography of Vanadium Chloroperoxidase and Its Directed Evolution P395D/L241V/T343A Mutant: Protonation Environments of the Active Site. Journal of the American Chemical Society, 137(16), 5618-5628. https://doi.org/10.1021/jacs.5b02635 [details]
- Hartog, A. F., & Wever, R. (2015). Substrate engineering and its synthetic utility in the sulfation of primary aliphatic alcohol groups by a bacterial arylsulfotransferase. Advanced Synthesis & Catalysis, 357(12), 2629-2632. https://doi.org/10.1002/adsc.201500482 [details]
- Sabuzi, F., Churakova, E., Galloni, P., Wever, R., Hollmann, F., Floris, B., & Conte, V. (2015). Thymol bromination: a comparison between enzymatic and chemical catalysis. European Journal of Inorganic Chemistry, 2015(21), 3519-3525. https://doi.org/10.1002/ejic.201500086 [details]
- Tasnádi, G., Lukesch, M., Zechner, M., Jud, W., Hall, M., Ditrich, K., ... Faber, K. (2015). Exploiting acid phosphatases in the synthesis of phosphorylated monoalcohols and diols. European Journal of Organic Chemistry, 2016(1), 45-50. https://doi.org/10.1002/ejoc.201501306 [details]
- Wever, R., Babich, L., & Hartog, A. F. (2015). Transphosphorylation. In K. Faber, W. D. Fessner, & N. J. Turner (Eds.), Biocatalysis in organic synthesis. - 1 (pp. 223-253). (Science of Synthesis; No. 2014, 5). Stuttgart: Thieme Verlag. [details]
- van der Horst, M. A., Hartog, A. F., El Morabet, R., Marais, A., Kircz, M., & Wever, R. (2015). Enzymatic Sulfation of Phenolic Hydroxy Groups of Various Plant Metabolites by an Arylsulfotransferase. European Journal of Organic Chemistry, 2015(3), 534-541. https://doi.org/10.1002/ejoc.201402875 [details]
2013
- Babich, L., Peralta, J. L. V. M., Hartog, A. F., & Wever, R. (2013). Phosphorylation by alkaline phosphatase: immobilization and synthetic potential. International Journal of Chemistry, 5(3), 87-98. https://doi.org/10.5539/ijc.v5n3p87 [details]
- Marhol, P., Hartog, A. F., van der Horst, M. A., Wever, R., Purchartová, K., Fuksova, K., ... Křen, V. (2013). Preparation of silybin and isosilybin sulfates by sulfotransferase from Desulfitobacterium hafniense. Journal of Molecular Catalysis B-Enzymatic, 89, 24-27. https://doi.org/10.1016/j.molcatb.2012.12.005 [details]
- Wever, R., & van der Horst, M. A. (2013). The role of vanadium haloperoxidases in the formation of volatile brominated compounds and their impact on the environment. Dalton Transactions, 42(33), 11778. https://doi.org/10.1039/c3dt50525a [details]
2012
- Babich, L., Hartog, A. F., van Hemert, L. J. C., Rutjes, F. P. J. T., & Wever, R. (2012). Synthesis of carbohydrates in a continuous flow reactor by immobilized phosphatase and aldolase. ChemSusChem, 5(12), 2348-2353. https://doi.org/10.1002/cssc.201200468 [details]
- Babich, L., Hartog, A. F., van der Horst, M. A., & Wever, R. (2012). Continuous-flow reactor-based enzymatic synthesis of phosphorylated compounds on a large scale. Chemistry - A European Journal, 18(21), 6604-6609. https://doi.org/10.1002/chem.201200101 [details]
- But, A., Le Notre, J., Scott, E. L., Wever, R., & Sanders, J. P. M. (2012). Selective oxidative decarboxylation of amino acids to produce industrially relevant nitriles by vanadium chloroperoxidase. ChemSusChem, 5(7), 1199-1202. https://doi.org/10.1002/cssc.201200098 [details]
- Natalio, F., Andre, R., Hartog, A. F., Stoll, B., Jochum, K. P., Wever, R., & Tremel, W. (2012). Vanadium pentoxide nanoparticles mimic vanadium haloperoxidases and thwart biofilm formation. Nature Nanotechnology, 7, 530-535. https://doi.org/10.1038/NNANO.2012.91 [details]
- Persoon, I. F., Hoogenkamp, M. A., Bury, A., Wesselink, P. R., Hartog, A. F., Wever, R., & Crielaard, W. (2012). Effect of Vanadium chloroperoxidase on Enterococcus faecalis biofilms. The Journal of Endodontics, 38(1), 72-74. https://doi.org/10.1016/j.joen.2011.09.003 [details]
- Wever, R., & van Herk, T. (2012). Hydrolysis and formation of P-O bonds. In K. Drauz, H. Gröger, & O. May (Eds.), Enzyme catalysis in organic synthesis. - 3rd ed. (pp. 1001-1033). Weinheim: Wiley-VCH. https://doi.org/10.1002/9783527639861.ch25 [details]
- van der Horst, M. A., van Lieshout, J. F. T., Bury, A., Hartog, A. F., & Wever, R. (2012). Sulfation of various alcoholic groups by an arylsulfate sulfotransferase from Desulfitobacterium hafniense and synthesis of estradiol sulfate. Advanced Synthesis & Catalysis, 354(18), 3501-3508. https://doi.org/10.1002/adsc.201200564 [details]
2011
- André, R., Natálio, F., Humanes, M., Leppin, J., Heinze, K., Wever, R., ... Tremel, W. (2011). V2O5 nanowires with an intrinsic peroxidase-like activity. Advanced Functional Materials, 21(3), 501-509. https://doi.org/10.1002/adfm.201001302 [details]
- Babich, L., van Hemert, J. C., Bury, A., Hartog, A. F., Falcicchio, P., van der Oost, J., ... Rutjes, F. P. J. T. (2011). Synthesis of non-natural carbohydrates from glycerol and aldehydes in a one-pot four-enzyme cascade reaction. Green Chemistry, 13(10), 2895-2900. https://doi.org/10.1039/c1gc15429j [details]
- Hartog, A. F., van Herk, T., & Wever, R. (2011). Efficient regeneration of NADPH in a 3-enzyme cascade reaction by in situ generation of glucose 6-phosphate from glucose and pyrophosphate. Advanced Synthesis & Catalysis, 353(13), 2339-2344. https://doi.org/10.1002/adsc.201100198 [details]
- Natalio, F., André, R., Pihan, S. A., Humanes, M., Wever, R., & Tremel, W. (2011). V(2)O(5) nanowires with an intrinsic iodination activity leading to the formation of self-assembled melanin-like biopolymers. Journal of Materials Chemistry, 21(32), 11923-11929. https://doi.org/10.1039/c1jm11811k [details]
2010
- Renirie, R., Charnock, J. M., Garner, C. D., & Wever, R. (2010). Vanadium K-edge XAS studies on the native and peroxo-forms of vanadium chloroperoxidase from Curvularia inaequalis. Journal of inorganic biochemistry, 104(6), 657-664. https://doi.org/10.1016/j.jinorgbio.2010.02.007 [details]
2009
- Caiazzo, A., Garcia, P. M. L., Wever, R., van Hest, J. C. M., Rowan, A. E., & Reek, J. N. H. (2009). Synergy between chemo- and bio-catalysts in multi-step transformations. Organic & Biomolecular Chemistry, 7(14), 2926-2932. https://doi.org/10.1039/b901592b [details]
- Hoogenkamp, M. A., Crielaard, W., ten Cate, J. M., Wever, R., Hartog, A. F., & Renirie, R. (2009). Antimicrobial activity of vanadium chloroperoxidase on planktonic Streptococcus mutans cells and Streptococcus mutans biofilms. Caries Research, 43(5), 334-338. https://doi.org/10.1159/000231569 [details]
- Renirie, R., Pierlot, C., Wever, R., & Aubry, J-M. (2009). Singlet oxygenation in microemulsion catalysed by vanadium chloroperoxidase. Journal of Molecular Catalysis B-Enzymatic, 56(4), 259-264. https://doi.org/10.1016/j.molcatb.2008.05.014 [details]
- van Herk, T., Hartog, A. F., Babich, L., Schoemaker, H. E., & Wever, R. (2009). Improvement of an acid phosphatase/DHAP-dependent aldolase cascade reaction by using directed evolution. ChemBioChem, 10(13), 2230-2235. https://doi.org/10.1002/cbic.200900102 [details]
2008
- Renirie, R., Dewilde, A., Pierlot, C., Wever, R., Hober, D., & Aubry, J-M. (2008). Bactericidal and virucidal activity of the alkalophilic P395D/L241V/T343A mutant of vanadium chloroperoxidase. Journal of Applied Microbiology, 105(1), 264-270. https://doi.org/10.1111/j.1365-2672.2008.03742.x [details]
- de Macedo-Ribeiro, S., Renirie, R., Wever, R., & Messerschmidt, A. (2008). Crystal structure of a trapped phosphate intermediate in vanadium apochloroperoxidase catalyzing a dephosphorylation reaction. Biochemistry, 47(3), 929-934. https://doi.org/10.1021/bi7018628 [details]
2012
- Auriol, D., ter Halle, R., Lefèvre, F., Visser, D. F., Gordon, G. E. R., Bode, M. L., ... Gruber-Khadjawi, M. (2012). Transferases for alkylation, glycosylation and phosphorylation. In J. Whittall, & P. W. Sutton (Eds.), Practical methods for biocatalysis and biotransformations (Vol. 2, pp. 231-262). Chichester: Wiley. https://doi.org/10.1002/9781119943426.ch9 [details]
- Kim, B. G., Ahn, J. H., Sello, G., Di Gennaro, P., van Herk, T., Hartog, A. F., ... Eddowes, P. (2012). Tandem and sequential multi-enzymatic syntheses. In J. Whittall, & P. W. Sutton (Eds.), Practical methods for biocatalysis and biotransformations (Vol. 2, pp. 313-346). Chichester: Wiley. https://doi.org/10.1002/9781119943426.ch12 [details]
- Wever, R. (2012). Structure and function of vanadium haloperoxidases. In H. Michibata (Ed.), Vanadium: biochemical and molecular biological approaches (pp. 95-125). Springer. https://doi.org/10.1007/978-94-007-0913-3_5 [details]
2010
- Wever, R. (2010). Application of peroxidases. In H. B. Dunford (Ed.), Peroxidases and catalases: biochemistry, biophysics, biotechnology, and physiology (2. ed.) (pp. 403-424). Hoboken, NJ: Wiley. [details]
- Wever, R., & Renirie, R. (2010). Structure and function of vanadium haloperoxidases. In H. B. Dunford (Ed.), Peroxidases and catalases: biochemistry, biophysics, biotechnology, and physiology (pp. 363-386). Wiley: Hoboken, NJ. [details]
Prize / grant
- Wever, R. (2016). Vanadis award.
Talk / presentation
- Wever, R. (speaker) (6-11-2016). Vanadium haloperoxidases, from their discovery to their involvement in ozone breakdown in the atmosphere, International Vanadium Symposium: Chemistry, Biological Chemistry, and Toxicology, Taipei.
Others
- Wever, R. (participant) (6-10-2022). Enzymology -Past, Present and Future, Utrecht. Co-organizer Enzymology Symposium, “Enzymology -Past, Present and Future, Utrecht, October 6, 2022 (organising a conference, workshop, ...).
- Wever, R. (visiting researcher) (18-1-2019). University of Copenhagen, Faculty of Science (visiting an external institution).
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Ancillary activities
No ancillary activities
Chen, S., Zhang, J., Zeng, Z., Dai, Z., Wang, Q., Wever, R., Hollmann, F., & Zhang, W. (2022). Chemoenzymatic intermolecular haloether synthesis. Molecular Catalysis, 517, [112061].